Precision Navigation of Hepatic Ischemia–Reperfusion Injury Guided by Lysosomal Viscosity-Activatable NIR-II Fluorescence. Jihong Liu, Wen Zhang, Chunmiao Zhou, Mengmei Li, Xin Wang, Wei Zhang, Zhenzhen Liu, Luling Wu, Tony D.Simultaneous Monitoring of HOCl and Viscosity with Drug-Induced Pyroptosis in Live Cells and Acute Lung Injury. Zixuan Zhan, Qian Lei, Yongcheng Dai, Denian Wang, Quanwei Yu, Yi Lv, Weimin Li.

Bichromatic Imaging with Hemicyanine Fluorophores Enables Simultaneous Visualization of Non-alcoholic Fatty Liver Disease and Metastatic Intestinal Cancer. Weijia Xu, Senyao Liu, Zhaoming Chen, Fapu Wu, Wenwen Cao, Yang Tian, Hu Xiong.Rational Design of Novel Lipophilic Aggregation-Induced Emission Probes for Revealing the Dynamics of Lipid Droplets during Lipophagy and Ferroptosis. Rui Chen, Zilu Li, Chao Peng, Lei Wen, Lehui Xiao, Yinhui Li.Novel Meso-Benzothiazole-Substituted BODIPY-Based AIE Fluorescent Rotor for Imaging Lysosomal Viscosity and Monitoring Autophagy. Wen-Jing Shi, Ru Chen, Jinrong Yang, Yong-Feng Wei, Yuhui Guo, Zi-Zhou Wang, Jin-wu Yan, Li Niu.Polarity-Ultrasensitive and Lipophilicity-Enhanced Structurally Modified Hemicyanine for Two-Color Staining to Reveal Cell Apoptosis during Chemotherapy. Zan Li, Jiangkun Tan, Chunyu Gao, Zhihao Lu, Jinmao You, Jun-Jie Zhu.This article is cited by 146 publications. H–V is biocompatible, ready to prepare, and may be expected to be used in the study of viscosity and OH comprises the majority of the total reactive oxygen species in ferroptosis.OH generation and cytoplasmic viscosity increase.With the probe we find that ferroptosis is accompanied by significant OH and viscosity in two independent channels without spectral cross-interference.OH and viscosity with high sensitivity and selectivity, thereby achieving the detection of.Probe H–V shows completely separate spectral responses to OH and cytoplasmic viscosity during ferroptosis using a dual-functional fluorescence probe (H–V) that is designed via the molecular rotor strategy and the unique aromatic hydroxylation of.Herein, we characterize for the first time the changing behavior of OH) and cellular microenvironments such as viscosity alter in this process.However, it remains unclear how hydroxyl radical ( Ferroptosis, a new form of regulated cell death, results from the iron-dependent accumulation of lipid peroxides that are associated with reactive oxygen species.

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